Remedy · supplement
Collagen peptides
Also: hydrolyzed collagen, gelatin hydrolysate
A protein supplement with moderate recent evidence for knee OA symptoms.
Evidence by condition
Each grade reflects the research for Collagen peptides and that condition specifically.
- BKnee osteoarthritis
Oral collagen peptides modestly reduce knee OA pain and improve joint function over about 3–6 months vs placebo.
2 citation s
- Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials Meta-analysis 2025 · n=870 · Clinical and Experimental Rheumatology · PMID 39212129 · DOI 10.55563/clinexprheumatol/kflfr5
- Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials Meta-analysis 2023 · n=507 · Journal of Orthopaedic Surgery and Research · PMID 37717022 · DOI 10.1186/s13018-023-04182-w
- Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials
- CTendinopathy
Collagen or gelatin taken before loading exercise increased tendon collagen and cross-sectional area in healthy people; relief of actual tendon pain is not yet proven.
2 citation s
- Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties Randomized trial 2022 · n=40 · Scandinavian Journal of Medicine & Science in Sports · PMID 35403756 · DOI 10.1111/sms.14164
- Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis Randomized trial 2017 · n=8 · The American Journal of Clinical Nutrition · PMID 27852613 · DOI 10.3945/ajcn.116.138594
- Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties