Remedy · nutrient
Iron
Also: ferrous sulfate, ferrous fumarate, iron supplement
An essential mineral that improves restless legs — especially when iron stores are low.
Evidence by condition
Each grade reflects the research for Iron and that condition specifically.
- BRestless legs syndrome
Probably reduces RLS severity (IRLS −3.78, moderate certainty); the strongest, guideline-prioritized case is correcting low ferritin. Check iron status before supplementing.
1 citation
- Iron for the treatment of restless legs syndrome Systematic review 2019 · n=428 · Cochrane Database of Systematic Reviews · PMID 30609006 · DOI 10.1002/14651858.CD007834.pub3
- Iron for the treatment of restless legs syndrome
Iron is the one supplement with solid evidence for restless legs — but it should be guided by a blood test (ferritin/transferrin saturation), not taken blindly, because iron overload is harmful. It is the recommended first step when iron stores are low.