Remedy · supplement
Melatonin
Also: N-acetyl-5-methoxytryptamine
The sleep-timing hormone, sold as a supplement for insomnia.
Evidence by condition
Each grade reflects the research for Melatonin and that condition specifically.
- BInsomnia
Modestly shortens time to fall asleep and improves sleep quality; best for circadian/timing problems.
2 citation s
- Meta-analysis: melatonin for the treatment of primary sleep disorders Meta-analysis 2013 · n=1,683 · PLoS ONE · PMID 23691095 · DOI 10.1371/journal.pone.0063773
- Melatonin: What You Need To Know NCCIH · accessed 2026-06-21
- Meta-analysis: melatonin for the treatment of primary sleep disorders
- —Acid reflux (GERD)
A few small studies suggest reflux symptom benefit, but the evidence is preliminary.
1 citation
- Melatonin: What You Need To Know NCCIH · accessed 2026-06-21
- Melatonin: What You Need To Know