Remedy · nutrient
Niacinamide (topical)
Also: nicotinamide, vitamin B3 amide
A form of vitamin B3 that, applied as a gel, performs comparably to a topical antibiotic for inflammatory acne.
Evidence by condition
Each grade reflects the research for Niacinamide (topical) and that condition specifically.
- BAcne vulgaris
Topical ~4% gel reduces inflammatory acne about as well as topical clindamycin over 8 weeks; trials are small/older and mostly active-comparator.
2 citation s
- Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris Randomized trial 1995 · n=76 · International Journal of Dermatology · PMID 7657446
- Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris Randomized trial 2013 · n=80 · International Journal of Dermatology · PMID 23786503 · DOI 10.1111/ijd.12002
- Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris
Niacinamide is the non-flushing amide form of vitamin B3. Applied topically it matched a prescription antibiotic gel for inflammatory acne in head-to-head trials, with the advantage of no antibiotic- resistance concern. (This entry is about the topical form; oral niacinamide for acne is not well evidenced.)