Remedy · nutrient
Vitamin B6
Also: pyridoxine, pyridoxine hydrochloride
A vitamin that is a guideline-backed first option for pregnancy nausea.
Evidence by condition
Each grade reflects the research for Vitamin B6 and that condition specifically.
- BNausea & vomiting
Reduces nausea of pregnancy across trials and reviews (a recommended first-line therapy, often with doxylamine); the effect on vomiting frequency is weaker and less consistent.
2 citation s
- The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis Meta-analysis 2023 · Archives of Gynecology and Obstetrics · PMID 36719452 · DOI 10.1007/s00404-023-06925-w
- Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study Randomized trial 1991 · n=59 · Obstetrics & Gynecology · PMID 2047064
- The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis
- DCarpal tunnel syndrome
Long promoted for carpal tunnel, but controlled trials and a Cochrane review found no benefit on symptoms or nerve conduction.
2 citation s
- Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome Systematic review 2003 · n=50 · Cochrane Database of Systematic Reviews · PMID 12535461 · DOI 10.1002/14651858.CD003219
- Using pyridoxine to treat carpal tunnel syndrome: randomized control trial Randomized trial 1993 · n=32 · Canadian Family Physician · PMID 8219859
- Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome
Vitamin B6 is one of the few supplements that medical guidelines actively recommend — as a first-line option for nausea of pregnancy, often paired with doxylamine. Keep within recommended dosing, since sustained megadoses can cause nerve symptoms.