Research · Randomized controlled trial
A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
What it found
Antioxidants + zinc cut the odds of progressing to advanced AMD by ~25% (OR 0.72) in high-risk participants over ~6 years.
- Design
- Randomized controlled trial
- Year
- 2001
- Sample size
- 3,640
- Population
- adults aged 55–80 with varying severity of AMD
- Intervention
- antioxidant vitamins (C, E, beta-carotene) and/or zinc 80 mg + copper vs placebo
- Outcome
- progression to advanced AMD and vision loss
- Journal
- Archives of Ophthalmology
Citation last checked 2026-06-21.