Research · Randomized controlled trial
Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis
What it found
Butterbur was therapeutically equivalent to the antihistamine cetirizine over 2 weeks, with less sedation.
- Design
- Randomized controlled trial
- Year
- 2002
- Sample size
- 125
- Population
- adults with seasonal allergic rhinitis (butterbur 61, cetirizine 64)
- Intervention
- butterbur CO2 extract Ze 339, one tablet four times daily for 2 weeks
- Outcome
- health-related quality of life (SF-36) and global clinical improvement
- Journal
- BMJ
Citation last checked 2026-06-21.