Research · Randomized controlled trial
Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
What it found
Both butterbur and fexofenadine were significantly better than placebo, with no significant difference between the herb and the antihistamine.
- Design
- Randomized controlled trial
- Year
- 2005
- Sample size
- 330
- Population
- patients with intermittent allergic rhinitis (Petasites Study Group)
- Intervention
- butterbur Ze 339 three times daily vs fexofenadine vs placebo for 1 week
- Outcome
- change in rhinitis symptom scores
- Journal
- Phytotherapy Research
Citation last checked 2026-06-21.