Research · Randomized controlled trial
d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial
What it found
No significant benefit: 51.0% (D-mannose) vs 55.7% (placebo) had a further UTI (adjusted RR 0.92, P=.22); authors concluded D-mannose should not be recommended for prevention.
- Design
- Randomized controlled trial
- Year
- 2024
- Sample size
- 598
- Population
- women aged 18+ with recurrent UTI, 99 UK primary-care centres (MERIT)
- Intervention
- 2 g D-mannose powder once daily for 6 months vs placebo
- Outcome
- proportion with a further medically attended UTI within 6 months
- Journal
- JAMA Internal Medicine
Citation last checked 2026-06-21.