Research · Systematic review
Horse chestnut seed extract for chronic venous insufficiency
What it found
Reduced leg pain (most placebo-controlled trials) and leg volume (pooled −32 mL); a consistent short-term benefit, though Cochrane rated the underlying evidence low quality.
- Design
- Systematic review
- Year
- 2012
- Sample size
- 1,518
- Population
- adults with chronic venous insufficiency (17 RCTs)
- Intervention
- oral horse chestnut seed extract standardized to escin, ~2–16 weeks
- Outcome
- leg pain, leg volume/edema, pruritus
- Journal
- Cochrane Database of Systematic Reviews
Citation last checked 2026-06-21.