Research · Randomized controlled trial
Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris
What it found
After 8 weeks both gels improved acne comparably (82% vs 68% improved), with no statistically significant difference between nicotinamide and the antibiotic.
- Design
- Randomized controlled trial
- Year
- 1995
- Sample size
- 76
- Population
- patients with moderate inflammatory acne vulgaris (38 per arm)
- Intervention
- topical 4% nicotinamide gel vs 1% clindamycin gel, twice daily for 8 weeks
- Outcome
- global improvement, lesion counts, acne severity
- Journal
- International Journal of Dermatology
Citation last checked 2026-06-21.