Research · Meta-analysis
Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder
What it found
Overall benefit in major depression (SMD ~0.40); a higher EPA dose significantly predicted better outcomes, and the effect was clearest as an add-on to antidepressants.
- Design
- Meta-analysis
- Year
- 2016
- Sample size
- 1,233
- Population
- adults with major depressive disorder (13 RCTs)
- Intervention
- omega-3 supplementation (varying EPA dose) vs placebo
- Outcome
- change in depression severity
- Journal
- Translational Psychiatry
Citation last checked 2026-06-21.