Research · Randomized controlled trial
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression
What it found
Both Rhodiola doses significantly improved overall depression, insomnia, and emotional instability versus placebo, with no serious adverse effects — but the trial was small and short.
- Design
- Randomized controlled trial
- Year
- 2007
- Sample size
- 89
- Population
- adults aged 18–70 with mild-to-moderate depression
- Intervention
- SHR-5 extract 340 mg/day or 680 mg/day vs placebo, 6 weeks
- Outcome
- depression severity (Hamilton, Beck)
- Journal
- Nordic Journal of Psychiatry
Citation last checked 2026-06-21.