Research · Meta-analysis
S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
What it found
Found NO significant difference for SAMe versus placebo (as monotherapy or add-on) or versus imipramine/escitalopram; authors urged caution given few trials and a wide dose range.
- Design
- Meta-analysis
- Year
- 2024
- Sample size
- 1,522
- Population
- adults with depression (14 RCTs)
- Intervention
- SAMe as monotherapy or add-on vs placebo or antidepressants
- Outcome
- change in depression severity
- Journal
- General Hospital Psychiatry
Citation last checked 2026-06-21.