Research · Meta-analysis
Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: a systematic review and meta-analysis of randomized controlled trials
What it found
SAMe monotherapy beat placebo (SMD −0.58) with oral and intramuscular routes effective; a trend toward slightly less benefit than antidepressants. (A separate 2024 meta-analysis found no significant benefit — the evidence is mixed.)
- Design
- Meta-analysis
- Year
- 2024
- Sample size
- 2,234
- Population
- adults with depression (23 trials)
- Intervention
- SAMe vs placebo, vs antidepressants, or as add-on therapy
- Outcome
- reduction in depressive symptoms; acceptability
- Journal
- European Psychiatry
Citation last checked 2026-06-21.