Research · Randomized controlled trial
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
What it found
Vitamin D3 alone did not reduce fractures — total HR 0.98, hip HR 1.01 — in adults who were not vitamin-D-deficient. (Does not apply to correcting overt deficiency.)
- Design
- Randomized controlled trial
- Year
- 2022
- Sample size
- 25,871
- Population
- generally healthy US adults not selected for vitamin D deficiency (VITAL)
- Intervention
- vitamin D3 2000 IU/day vs placebo (no supplemental calcium)
- Outcome
- incident total, nonvertebral, and hip fractures
- Journal
- New England Journal of Medicine
Citation last checked 2026-06-21.