Research · Randomized controlled trial
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis (PIVENS)
What it found
Histologic improvement in 43% vs 19% placebo; no improvement in fibrosis.
- Design
- Randomized controlled trial
- Year
- 2010
- Sample size
- 247
- Population
- non-diabetic adults with biopsy-proven NASH
- Intervention
- vitamin E 800 IU/day
- Outcome
- liver histology
- Journal
- New England Journal of Medicine
Citation last checked 2026-06-21.