Remedy · supplement
Coenzyme Q10
Also: CoQ10, ubiquinone, ubiquinol
A mitochondrial antioxidant with moderate evidence for migraine prevention.
Evidence by condition
Each grade reflects the research for Coenzyme Q10 and that condition specifically.
- BMigraine
About 300 mg/day modestly reduced migraine frequency and days, and was well tolerated.
1 citation
- Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial Randomized trial 2005 · n=42 · Neurology · PMID 15728298 · DOI 10.1212/01.WNL.0000151975.03598.ED
- Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial
- DHigh blood pressure
A Cochrane review found no clinically significant effect on blood pressure in primary hypertension.
2 citation s
- Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension Systematic review 2016 · n=50 · Cochrane Database of Systematic Reviews · PMID 26935713 · DOI 10.1002/14651858.CD007435.pub3
- Complementary Health Approaches for Hypertension: What the Science Says NCCIH · accessed 2026-06-21
- Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension
- DFibromyalgia
Two very small trials suggest CoQ10 may reduce fibromyalgia pain and fatigue, but it is not independently replicated.
1 citation
- Can coenzyme Q10 improve clinical and molecular parameters in fibromyalgia? Randomized trial 2013 · n=20 · Antioxidants & Redox Signaling · PMID 23458405 · DOI 10.1089/ars.2013.5260
- Can coenzyme Q10 improve clinical and molecular parameters in fibromyalgia?