Remedy · nutrient
Riboflavin (vitamin B2)
Also: vitamin B2, B2
A B-vitamin with reasonable evidence for preventing migraines at high doses, and an excellent safety profile.
Evidence by condition
Each grade reflects the research for Riboflavin (vitamin B2) and that condition specifically.
- BMigraine
High-dose riboflavin (400 mg/day) reduced migraine frequency with a low number-needed-to-treat.
2 citation s
- Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial Randomized trial 1998 · n=55 · Neurology · PMID 9932987 · DOI 10.1212/WNL.50.2.466
- Riboflavin — Health Professional Fact Sheet NIH ODS · accessed 2026-06-21
- Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial