Research · Randomized controlled trial
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study
What it found
In the severe-nausea subgroup, B6 reduced nausea more than placebo and lowered the proportion still vomiting; little benefit in mild-to-moderate cases.
- Design
- Randomized controlled trial
- Year
- 1991
- Sample size
- 59
- Population
- pregnant women with nausea and vomiting (31 B6, 28 placebo)
- Intervention
- pyridoxine 25 mg orally every 8 hours for 72 hours vs placebo
- Outcome
- nausea severity and vomiting episodes
- Journal
- Obstetrics & Gynecology
Citation last checked 2026-06-21.