Research · Randomized controlled trial
Petasites hybridus root (butterbur) is an effective preventive treatment for migraine
What it found
75 mg twice daily cut migraine frequency 48% vs 26% placebo.
- Design
- Randomized controlled trial
- Year
- 2004
- Sample size
- 245
- Population
- adults with migraine
- Intervention
- PA-free butterbur extract
- Outcome
- attack frequency
- Journal
- Neurology
Citation last checked 2026-06-21.