Research · Systematic review
Iron for the treatment of restless legs syndrome
What it found
Iron probably improves RLS severity (IRLS −3.78; moderate certainty); benefit seen across iron status, but low ferritin is the guideline-prioritized scenario. Check ferritin before supplementing.
- Design
- Systematic review
- Year
- 2019
- Sample size
- 428
- Population
- adults with restless legs syndrome (10 RCTs)
- Intervention
- oral or intravenous iron vs placebo
- Outcome
- RLS severity (IRLS scale)
- Journal
- Cochrane Database of Systematic Reviews
Citation last checked 2026-06-21.