Research · Meta-analysis
Evaluation of clinical meaningfulness of red clover (Trifolium pratense) extract to relieve hot flushes and menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials
What it found
Reduced daily hot flushes by ~1.7 (significant), strongest at higher doses and in women with frequent flushes; a separate meta-analysis found the effect non-significant, so results are inconsistent.
- Design
- Meta-analysis
- Year
- 2021
- Sample size
- 1,179
- Population
- peri- and postmenopausal women (8 RCTs)
- Intervention
- red clover isoflavone extract vs placebo
- Outcome
- hot flush frequency
- Journal
- Nutrients
Citation last checked 2026-06-21.