Research · Meta-analysis
Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials
What it found
Found no convincing effect on bone density or vertebral fractures once high-bias trials were removed; a possible reduction in clinical fractures was judged insufficient to confirm.
- Design
- Meta-analysis
- Year
- 2019
- Population
- adults, predominantly postmenopausal/osteoporotic (36 RCTs)
- Intervention
- oral vitamin K supplementation for at least 6 months
- Outcome
- bone mineral density and clinical/vertebral fractures
- Journal
- Osteoporosis International
Citation last checked 2026-06-21.