Research · Meta-analysis
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials
What it found
Reported improved lumbar-spine bone density and lower fracture incidence in postmenopausal women, with no excess adverse events — though most data are from postmenopausal/Japanese cohorts.
- Design
- Meta-analysis
- Year
- 2022
- Sample size
- 6,425
- Population
- postmenopausal women (16 RCTs)
- Intervention
- vitamin K2 (MK-7 or MK-4), alone or with vitamin D / calcium
- Outcome
- lumbar-spine BMD, fracture incidence, bone-turnover markers
- Journal
- Frontiers in Public Health
Citation last checked 2026-06-21.