Research · Meta-analysis
Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
What it found
Soy isoflavones reduced hot flash frequency by ~21% and severity by ~26% versus placebo, with a dose-response for higher-genistein products.
- Design
- Meta-analysis
- Year
- 2012
- Population
- menopausal women (17 RCTs pooled)
- Intervention
- soy isoflavone supplements vs placebo
- Outcome
- hot flash frequency and severity
- Journal
- Menopause
Citation last checked 2026-06-21.